Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P

Physical aim and you will pharmacology out-of curcumin

Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin ‘s the significant part of the newest red-colored color of turmeric, an enthusiastic Indian liven that’s obtained from the latest rhizome of your exotic bush Curcuma longa, and that is one of the Zingiberaceae relatives. Within section, we discuss the pharmacological activities out-of curcumin and you can speak about the newest unit basics for those products. We then remark the newest shown and you can prospective health-related spends out-of curcumin. Curcumin is famous over the years because a curative agent, however, its mechanism regarding action try intricate. This new pharmacological negative effects of curcumin be seemingly the consequence of good synergism from networks from weakened biochemical interactions having numerous biological goals in interconnected signaling pathways. This type of purpose is enzymes particularly cyclooxygenase, lipoxygenase and you can healthy protein kinases, and you may transcription factors such as for instance NF-?B, STAT and you will Nrf2. Modulation of them particles affects downstream affectors that produce the new antiinflammatory, antioxidant, chemopreventive, treffimaan kaverit anticancer, and antimicrobial circumstances of curcumin. Such effects was basically looked at from inside the scientific trials of curcumin to own serious pain and you can inflammatory sickness, cancer tumors, Alzheimer problem, aerobic disease, and diabetic issues. The new examples have tried changeable doses of curcuminwith different frequencies and you can duration, to the standard achievement you to definitely highest dosages away from curcumin from the amount of grams have to get healing effects. Find out more

Curcumin: Synthesis, Growing Character from inside the Discomfort Government and you will Fitness Implications

Publication Part Types of plant-derived pharmaceuticals having get to be the interest out of proceeded and rapid look and innovation notice possess, thus far, already been slightly scarce. Immediately after several years, the last two decades had been characterized by an excellent 100-fold upsurge in exactly how many medical articles authored annually one is of significance on usage of curcumin when you look at the biomedicine. Find out more

Design, synthesis and you may physical circumstances out of curcumin prodrugs

Guide ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin has some potential pharmacological effects and can even enjoys therapeutic programs in many situation states, because talked about in more detail in the previous chapter. However, the potential scientific efficacy out of curcumin is restricted because of the its physicochemical qualities of poor drinking water solubility and you will imbalance, which cause lowest bioavailability. Prodrugs out of curcumin offer an effective way to improve of your own biopharmaceutical and you will pharmacokinetic attributes, that can ensure it is exploitation of one’s pharmacological ramifications of curcumin. Within chapter, i basic opinion the latest physicochemical and pharmacokinetics of curcumin. We upcoming explain the design of curcumin prodrugs having enhanced liquid solubility and you will improved chemical substances balance which are often translated back into 100 % free curcumin through to bioactivation into the vivo. We highlight recent success in this field, which have a focus on the structure, synthesis and you may review regarding prodrugs according to promoieties together with amino acids, efas, nucleic acids, dicarboxylic acids, and you will polymeric product like hyaluronic acid and you may polyethylene glycol. That it part provides the cause for optimisation of one’s physicochemical and you may biopharmaceutical services and physical items from curcumin prodrugs, into the purpose using of them curcumin types during the clinical applications. Read more